MY RESEARCH ARCHIVES

Bacteria in the Gut Influence Brians of Mice


This is an interesting topic for me regarding Alopecia and Gut Bacteria.

There are many many triggers for Alopecia, and that is one of the MANY EXCUSES made by our own community as to why research is not happening.  Quite often I hear people saying , “It would be so hard to cure because so many different triggers seem to initiate the onset of the disease…. so how on earth could we ever find a cure?”

Many triggers are:

The contraceptive pill

Massive trauma (family bereavement, divorce etc)

Injections

Pregnancy/puberty (hormonal Influences)

Stress

Overuse of Antibiotics

 

Well here is some research to how even the bacteria in ones gut can affect hormone secretion…..

What we must remember is that , although there seem to be many triggers which seem to cause Alopecia, the end result is exactly  the same….. an immune response is created in the body which results in our hair follicles being attacked.

 

This article below was published in August 2011 and poses interesting reading…

Anyone who has ever had a stomach bug knows it can really subdue your spirits as well as your appetite. But other parts of the gut microbiome can have the opposite effect, and make you feel great. Irish researchers have found a type of gut bacteria that seems to have directly interacted with the brains of mice, reducing stress and depression.

Scientists fed mice a broth containing Lactobacillus rhamnosus, a strain of Lactobacillus species that is found in mouse gastrointestinal systems, and watched the mice’s behavior. They appeared less stressed and depressed than mice who got a plain broth, the researchers reported. When they were placed in water to deliberately stress them out, the L. rhamnosus-fed mice also had lower levels of stress hormones.

John Cryan, a neuroscientist at University College Cork in Ireland, also monitored the animals’ brains to watch for changes. He and colleagues found heightened activity in one of the receptors for a neurotransmitter called GABA, which regulates psychological processes. Certain depression drugs target GABA receptors, ScienceNow points out. Cryan and his colleagues found that certain portions of the neurotransmitter that are normally reduced during depression were more highly expressed in the L. rhamnosus mice. And other areas that are increased during depression were less pronounced in the L. rhamnosusmice.

 

To prove there really was a connection between the stomach bacteria and GABA activity, the researchers got new mice and cut the nerve that allows the gastrointestinal tract to communicate with the central nervous system. Then they fed these mice the broth, and the GABA receptors and mouse behavior remained at normal, pre-bacteria-enhanced levels.

This is not the first study to examine a connection between gut bacteria and psychological/brain physiological changes. Last summer, a British study found that the urine of autistic children has a distinct chemical signature associated with gut bacteria. Researchers at Imperial College London were not sure whether the bacteria were producing some kind of metabolic byproducts that could contribute to autism.

The Irish researchers say they still want to determine how the bacteria interact with the GABA receptors.

The chose L. rhamnosus because they happened to have it handy, and because related Lactobacillus species are so common in “probiotic” food supplements, ScienceNow reports. The bacteria is used to make foods like sourdough bread, yogurt and cheese.

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