It is common knowledge that for years Stomach Ulcers in the medical world were thought to be caused by ….. guess what?……… STRESS and spicy foods!
Get some rest, de-stress and the stomach ulcers will just disappear? Ye right! Does the beginning of this story sound familiar to anyone???
Helicobacter Pylori is a Gram-negative, microaerophilic bacterium found in the stomach and more than 50% of the world’s population harbor H. pylori in their upper gastrointestinal tract.
Dr Barry Marshall, an Australian Physician won a nobel prize in 1982 for discovering that Stomach Ulcers or Gasteritis were caused by the bacterium, Helicbacter Pylori. Knowing that reseaarch was going to take years and years with in vitro studies and then animal studies before progressing to human studies this remarkable physician took matters into his own hands to prove his theory.
Dr Barry Marshall drank a Petri dish containing cultured H. pylori, expecting to develop, perhaps years later, an ulcer. He was surprised when, only three days later, he developed vague nausea and halitosis, (due to the achlorhydria, there was no acid to kill bacteria in the stomach, and their waste products manifested as bad breath), noticed only by his mother. On days 5–8, he developed achlorydric (no acid) vomiting. On day eight, he had a repeat endoscopy and biopsy, which showed massive inflammation (gastritis), and H. pylori was cultured. On the fourteenth day after ingestion, a third endoscopy was done, and Marshall began to take antibiotics.
The mystery was then solved and through his work around 500 000 people lives are saved every year.
SOMETIMES TAKING RISKS AND THINKING OUTWITH THE BOX ARE MANDATORY TO RESEARCH PROGRESSION.
THANK GOODNESS BARRY WENT WITH HIS GUT INSTINCT ON THIS ONE!
Please click on the link for an interview with Barry Marshall.
I was tested for Helicobacter Pylori and the test results came back negative. Much to my dismay. this bacterium is becoming increasingly difficult to erradicate through different strains of it developing. Triple courses of antibiotics seem to be the most popular treatment, however these are not always successful. Many of my Alopecia clients do suffer…
- Acid Reflux
- Stomach Ulcers
- Food Allergies
Cure of alopecia areata after eradication of Helicobacter pylori: A new association?
Correspondence to: Dr. Germán Campuzano-Maya, Professor, Ad honorem, Faculty of Medicine, University of Antioquia. Medical Director, Laboratorio Clínico Hematológico, Carrera 43C No. 5-33, Medellín, Colombia.
Alopecia areata is a disease of the hair follicles, with strong evidence supporting autoimmune etiology. Alopecia areata is frequently associated with immune-mediated diseases with skin manifestations such as psoriasis and lichen planus, or without skin manifestations such as autoimmune thyroiditis and idiopathic thrombocytopenic purpura. Helicobacter pylori (H. pylori) infection is present in around 50% of the world’s population and has been associated with a variety of immune-mediated extra-digestive disorders including autoimmune thyroiditis, idiopathic thrombocytopenic purpura, and psoriasis. A case of a 43-year old man with an 8-mo history of alopecia areata of the scalp and beard is presented. The patient was being treated by a dermatologist and had psychiatric support, without any improvement. He had a history of dyspepsia and the urea breath test confirmed H. pylori infection. The patient went into remission from alopecia areata after H. pylori eradication. If such an association is confirmed by epidemiological studies designed for this purpose, new therapeutic options could be available for these patients, especially in areas where infection with H. pylori is highly prevalent.
Alopecia areata is a disease of the hair follicles, with strong evidence supporting an autoimmune origin, although the exact pathogenesis of the disease is not clear. Alopecia areata has a frequency ranging from 0.7% to 3.8% in patients attending dermatology clinics, affects both sexes, and a familial occurrence is often reported[3,4]. The pattern of hair loss can vary and can affect any part of the body. Alopecia areata frequently occurs in association with other autoimmune diseases, including autoimmune thyroiditis, psoriasis[6–8] and Sjögren syndrome, among others.
Helicobacter pylori (H. pylori) is a microaerophilic Gram-negative bacterium that colonizes the gastric mucosa and is present in around 50% of the world’s population, with varying prevalence rates between 7% in the Czech Republic and 87% in a South African population. In the case of Medellín, Colombia, prevalence of H. pylori infection in children under 12 years is 60.9% and in adults, it is 77.2%. H. pylori infection has been associated with the pathogenesis of gastric disorders such as gastritis, duodenal and gastric ulcers, gastric cancer, mucosa-associated lymphoid tissue lymphoma, and a variety of extra-digestive disorders, many of them clearly identified as immune-mediated, such as idiopathic thrombocytopenic purpura[16,17], autoimmune thyroiditis[18,19], Sjögren’s syndrome[20,21], rosacea and psoriasis[23,24].
A case of a 43-year-old man with patchy alopecia areata and H. pylori infection is presented. The patient had hair regrowth after bacterial eradication.
A 43-year-old man presented with an 8-mo history of patchy hair loss in the scalp and beard (Figure 1A-C). He had consulted a dermatologist who prescribed 0.25% desoximetasone and 5% minoxidil, according to the guidelines for the management of alopecia, and had psychiatric support with escitalopram 5 mg/d, without any response other than progression of the condition.
Photographic sequence of lesions before and after Helicobacter pylori eradication. A-C: Alopecia areata of the scalp (A and B) and beard (C) at baseline visit (week 0) before Helicobacter pylori (H. pylori) eradication. Positive 13C-UBT (6.95 δ …
The patient had a history of dyspepsia, therefore, he underwent analysis to determine H. pylori status. Urea breath test (13C-UBT) (6.95 δ13CO2; negative, < 1), and H. pylori IgG antibodies (IgG index: 52.4; negative, < 9) were positive. Subsequent laboratory evaluation included normal values of ultrasensitive thyroid stimulating hormone, free thyroxine and free tri-iodothyronine; and negative antinuclear, antithyroid peroxidase and intrinsic factor antibodies. The patient was prescribed first line H. pylori eradication with proton pump inhibitor (omeprazole) 20 mg twice daily, amoxicillin 1000 mg twice daily, and clarithromycin 500 mg twice daily for 14 d, according to recommendations from the Maastricht III Consensus Report, and was followed photographically every 2 wk. He was instructed not to take or apply any medications for alopecia areata. H. pylori eradication was confirmed 6 wk after treatment with a negative result of the 13C-UBT (0.81 δ13CO2).
Figure Figure11 shows the photographic sequence of the lesions before and after H. pylori eradication. From week 4, there was evidence of hair regrowth in the scalp and beard (Figure 1D-F). To date, the patient continues in complete remission from alopecia areata, as shown in Figure 1M-O.
H. pylori infection has been associated with numerous immune and non-immune disorders including dermatological conditions, such as chronic urticaria[28–30], rosacea[22,28,31–39], psoriasis[23,24], Schönlein-Henoch purpura[40–46], Behçet’s disease[47,48], prurigo nodularis, chronic cutaneous pruritus, progressive systemic sclerosis[51–54], Sjögren’s syndrome[20,21,55–57], and Sweet’s syndrome; many of them improving or going into remission after eradication of H. pylori infection[24,30,49,59–61]. Several mechanisms have been suggested to mediate the systemic effects of H. pylori infection, including the development of antigen-antibody complexes and cross-reactive antibodies (by molecular mimicry)[61–63], where antibodies developed against H. pylori cross-react with autoantigens to cause tissue damage, as has been reported in atrophic gastritis[62,64], chronic gastritis[65–67], chronic idiopathic thrombocytopenic purpura[16,17,68–70], Hashimoto’s thyroiditis, atherosclerosis, arterial hypertension, unstable angina pectoris, ischemic heart disease[74,75], Alzheimer’s disease, systemic sclerosis[77,78], central serous chorioretinopathy, iron deficiency[80,81], autoimmune pancreatitis[82–86], and chronic urticaria.
Alopecia areata has been described to be of autoimmune origin, with the presence of inflammatory cells around and within the human hair follicles. Alopecia areata has been associated with other autoimmune disorders including thyroid disease[89–93], psoriasis[6,7], and celiac disease[94–97]; conditions that have also been associated with H. pylori infection.
In the literature, there is ample evidence to suggest an association between H. pylori and alopecia areata that could explain the cure in this patient after eradication of infection. There is concurrent alopecia areata with immune diseases that are also concurrent with H. pylori infection. There are three different scenarios: immune-mediated skin diseases associated with H. pylori infection and alopecia areata, including psoriasis[6,7,23,24,98–103] and lichen planus[101,104–109]; immune-mediated non-skin conditions associated with H. pylori infection and alopecia areata, including autoimmune thyroiditis[18,19,110–115], celiac disease[94–97,116–118], idiopathic thrombocytopenic purpura[119,120], and autoimmune pancreatitis[82,84,85,121–124]; and laboratory findings that show the immunological nature of the conditions that are found in H. pylori-infected patients as well as in alopecia areata patients, including parietal cell antibodies[117,125–127] and thyroid antibodies[90,128].
After reviewing the medical literature, an association between H. pylori infection and alopecia areata has not been clearly demonstrated; only three reports have explored such association and had different results[129–131]. Abdel Hafez et al have compared 31 patients with alopecia areata with 24 healthy controls and have found no significant difference in the H. pylori status, as determined by an antigen stool test. Rigopoulos et al have compared H. pylori seroprevalence in 30 patients with alopecia areata and 30 healthy controls, and found no significant difference between the groups, whereas Tosti et al have found, in a group of 68 patients with alopecia areata, that the seroprevalence of H. pylori infection was higher than in matched controls. It is of note that the presence of IgG antibodies against H. pylori does not confirm current infection and is only an indicator of previous exposure to the bacterium. However, none of the studies tried to eradicate the infection and evaluate posterior hair regrowth.
Here, I have described the case of one patient who had patchy hair loss of the scalp and beard. The patient’s condition started to improve within 4 wk of completing H. pylori eradication (Figure 1D-F). By week 16 (Figure 1J-L), the patient had completely reversed the hair loss, and by week 44 (Figure 1M-O), he remained H. pylori-negative and completely cured of alopecia areata. Although prior studies have only reported the prevalence of H. pylori infection in alopecia areata patients, to the best of my knowledge, this is the first documented case of reversed hair loss after H. pylori eradication.
There have been a few early studies in which antibiotic treatment was used in an attempt to cure alopecia areata, but in no case was there information on whether the patients were infected with H. pylori. Dapsone was used unsuccessfully[133,134]. There was one case of a 13-year-old girl with multiple autoimmune diseases who was successfully treated for alopecia areata with co-trimoxazole, a drug with antibiotic properties and immunomodulatory effects that could have been responsible for hair regrowth. Finally, there was one case in the literature describing the occurrence of alopecia areata after antibiotic treatment with rifampicin. However, further case-control studies could be useful to rule out this possibility completely.
Hence, a common denominator in various autoimmune diseases is H. pylori infection; therefore, H. pylori status could be determined in several autoimmune conditions, and if positive, eradication treatment could follow as an initial step. More studies are needed to clarify the reality of the proposed association.
Thank you once again for reading 🙂
Jayne Waddell xxx